Management Change/Compensation Form 8 K

Item 5.02 Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

On December 16, 2024, Ms. Chihiro Saito, Senior Vice President, Accounting and Financial Operations ("SVP, AFO") and Interim Principal Accounting Officer ("Interim PAO") of Tenaya Therapeutics, Inc. ("Tenaya" or the "Company") advised the Company that she was resigning from her role as SVP, AFO and Interim PAO to pursue another opportunity. Ms. Saito's resignation is not the result of any disagreement with Tenaya on any matter relating to Tenaya's financials, operations, policies or practices.